E-ISSN: 2146-8052
Contribution of prostate-specific antigen density in the prediction of prostate cancer: Does prostate volume matter?
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Original Article
VOLUME: 60 ISSUE: 1
P: 14-18
March 2018

Contribution of prostate-specific antigen density in the prediction of prostate cancer: Does prostate volume matter?

Gulhane Med J 2018;60(1):14-18
DOI: 10.26657/gulhane.00010
Murat Zor
Engin Kaya
Selahattin Bedir
1. Gulhane Training and Research Hospital, Urology, Ankara, Turkey
No information available.
No information available
Received Date: 07.01.2018
Accepted Date: 19.03.2018
Publish Date: 15.03.2018
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ABSTRACT

Aims:

We aimed to evaluate whether there is a specific subgroup of patients who benefit most from PSAD screening according to their prostate volume.

Methods:

Transrectal ultrasound guided prostate biopsy performed patients were stratified in five groups according to their prostate size. PSAD values were compared between groups, and the diagnostic accuracy of PSAD was evaluated for different prostate volumes.

Results:

Of 326 patients 98 (30.0%) had pCa. While total PSA and PSAD between pCa(+) and (-) patients were significantly higher in group 1,2 and 3, the differences was not significant in group 4 and 5. The highest AUC value was achieved for group 3 and the lowest for group 5. The optimal cutoff values were different between groups.

Conclusions:

Demonstrating the greatest diagnostic accuracy of PSAD in prostates ≥60 and <80 cc makes an invaluable contribution to the current literature and would be a reference point for further studies.