ABSTRACT

Mucinous colorectal carcinoma with signet ring cell component is investigated the clinicopathological and prognostic features in this study. 741 patients underwent resection due to colorectal carcinoma in our university hospital between 1994 and 2008 years. Mucinous carcinoma were seen in 99 patients. All pathology slides of mucinous carcinoma patients were re-examined. Lymphatic invasion, necrosis and ulceration have been assessed. Clinicopathologic features, survival times and statistical results were compared with mucinous carcinoma with signet ring cell component and without signet ring cell component in the study. Lymphatic invasion and lymph node metastasis were more frequent in mucinous carcinoma with signet ring cell component than mucinous carcinoma without signet ring cell component. (%32&%16 p=0.019) (p<0.0001) Mucinous carcinoma with signet ring cell component patients were %31.3 of mucinous carcinoma patients. Mucinous carcinoma patients were T3 and T4 tumours. Signet ring cells appear with extracellular mucin production. Signet ring cell component in mucinous cancer patients increases lymphatic invasion and lymph node metastasis. Distant metastases are more frequent in signet ring cell component patients. There were no statistically significant difference between patients on necrosis, ulceration, depth of invasion and tumor location. 5 years survive in signet ring cell component patients were %46.4 and in mucinous carcinoma without signet ring cell component was %59.4. In conclusion signet ring cell component was evaluated as a poor prognosis factor in mucinous carcinoma patients.

Keywords: Prognostic Significance of Signet Ring Cell Component