ABSTRACT

In this study we aimed to evaluate the cytotoxic effect of garlic extract on human gingival fibroblasts. Garlic extracts were prepared at 5 different concentrations as 12.5%, 6.25%, 3.12%, 1.5%, and 0.6%. Cytotoxic effects of garlic and clorhexidine gluconat (CH) on human gingival fibroblasts were evaluated by agar diffusion method at 24 h. Garlic extracts concentrations at 6.25, 3.12, and 1.5% were not found cytotoxic on human gingival fibroblasts, whereas concentration at 12.5% was found cytotoxic, this effect was found less cytotoxic than CH. According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.

Keywords: Garlic; chlorhexidin gluconat; human gingival fibroblast; cytotoxicity