E-ISSN: 2146-8052
Early predictors of preterm labor and preeclampsia: A prospective study
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Original Article
VOLUME: 59 ISSUE: 2
P: 33-38
June 2017

Early predictors of preterm labor and preeclampsia: A prospective study

Gulhane Med J 2017;59(2):33-38
DOI: 10.5455/Gulhane.208531
Ali Babacan 1
Özgür Dündar 1
Murat Muhcu 1
Ercüment Müngen 1
Vedat Atay 1
Cem Kızılaslan 2
Yaşam Kemal Akpak 3
1. Haydarpaşa Sultan Abdülhamid Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum AD, İstanbul,Türkiye.
2. Şehit Murat Erdi Eker Devlet Hastanesi, Kadın Hastalıkları ve Doğum AD, Ankara, Türkiye (eski kurum).
3. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Mevki Binası, Kadın Hastalıkları ve Doğum AD, Ankara,
No information available.
No information available
Received Date: 19.11.2015
Accepted Date: 05.08.2017
Publish Date: 30.06.2017
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ABSTRACT

Aims:

This study aimed to investigate various clinical/biochemical parameters as potential predictors of preeclampsia and preterm labor. MMP-2, MMP-9, pregnancy-associated plasma protein A (PAPP-A), fms-like tyrosine kinase 1, and beta human chorionic gonadotropin (β-HCG) levels were measured and Doppler ultrasonography measurements were made in pregnant women at 11-14 weeks of gestation. Findings were recorded and patients were followed until delivery.

Results:

Patients consisted of preeclampsia and/or preterm labor cases (n=40) and selected controls were pregnant women with a normal pregnancy period who delivered between 37 and 40 weeks of gestation (n=55). Multivariate analysis identified high fms-like tyrosine kinase 1 level (OR, 1.004; 95% CI: 1.001-1.007, p= 0.005), high UtA PI (OR, 30.6; 95% CI: 1.1-852, p= 0.044) and presence of any notch (OR, 36.4; 95% CI: 1.6-826, p= 0.024) as independent predictors of preeclampsia; whereas only maternal MMP-9 level emerged as a significant predictor of preterm birth, (OR, 1.001; 95% CI: 1.000-1.001, p< 0.001).

Conclusions:

These parameters deserve further investigation for their potential use (either alone or in combination) in the prediction of preeclampsia and preterm birth in the clinical setting.

Keywords:
preterm labor, preeclampsia, Doppler ultrasonography, matrix metalloproteinase (MMP), pregnancy-associated plasma protein A (PAPP-A), fms-like tyrosine kinase 1, beta human chorionic gonadotropin (β-HCG).