E-ISSN: 2146-8052
Comparison of Transdermal and Oral Progestin Combinations in Transdermal Estrogen Replacement Therapy: Effects on Serum Lipids and Lipoproteins
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Research
VOLUME: 49 ISSUE: 4
P: 311-314
December 2004

Comparison of Transdermal and Oral Progestin Combinations in Transdermal Estrogen Replacement Therapy: Effects on Serum Lipids and Lipoproteins

Gulhane Med J 2004;49(4):311-314
Reşide ÖNALAN 1
Göğşen ÖNALAN 2
Leyla MOLLAMAHMUTOĞLU 1
Belgin SELAM 1
Münire AKAR 1
1. Dr. Zekai Tahir Burak Kadın Sağlığı, Eğitim ve Araştırma Hastanesi/ANKARA
2. Ankara Eğitim ve Araştırma Hastanesi/ANKARA
No information available.
No information available
Accepted Date: 06.10.2004
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ABSTRACT

Objective:

We compared metabolic effects of transdermal and oral progestin combinations in postmenopausal women receiving transdermal estrogen replacement therapy.

Study Design:

One hundred fourteen postmenopausal women were randomized to receive either transdermal continous 17β estradiol, 0.05 mg/day with transdermal cyclic norethisterone acetate, 0.25 mg/day or transdermal continous 17β estradiol, 0.05 mg/day with oral cyclic medroxiprogesteron acetate, 10mg/day. Women in two groups were studied for one year. Lipoprotein profiles at 3,6 and 12 months were compared with baseline values by means of analysis of variance.

Results:

Plasma total cholesterol, low (LDL) and high (HDL) density lipoprotein and trigliserides were all significatly reduced.

Argument:

Transdermal and oral progestin combinations in transdermal estrogen replacement therapy have similar effects on serum lipids and lipoproteins.

Keywords:
Transdermal, Postmenopausal, Estradiol, Progestin, Plasma Lipids, Plasma lipoproteins, Cholesterol