ABSTRACT

The aim of the study was to compare the results calculated by automatic and semiautomatic methods in the multigated analysis (MUGA) scans and to research the correlation between the results calculated by both modalities. 30 patients including 18 (60%) men and 12 (40%) women (Age, mean±SD:15±8) were included into the study. Systolic parameters such as left ventricular ejection fraction (LVEF) and peak emptying rate (PER) together with diastolic parameters such as peak filling rate (PFR) and time-to-peak filling rate” (TTPFR) derived by automatic and semiautomatic analysis in MUGA scans were compared. These measurements were made by two nuclear medicine specialists and "interobserver" variability was also investigated. The results of EF, PER, PFR, and TTPFR were calculated by automatic and semiautomatic methods and levels of significance were 59,04±10,41 57,63±9,5 (p=0,134), 3,28±0,74, 3,42±0,79 (p=0,054), 3.48±1,03, 3,72±0,97 (p=0,030), 120,41±30,94, 116,73±35,37 (p=0,459), respectively, and statistically significant difference between the parameters except PER was not detected. When the automatic and semiautomatic analyses of both specialists were compared, statistically significant difference between the parameters except LVEF was not detected. The difference between the calculations of both methods was decreased in the semiautomatic analysis. Although there was not a statistically significant difference between the results of the systolic and diastolic functional parameters that were analyzed by automatic and semiautomatic analyses, the preference of semiautomatic analysis for LVEF calculations seems to give more precise results by decreasing the interobserver variability.

Keywords: MUGA, leftventricularejectionfraction, diastolicfunction