E-ISSN: 2146-8052
Activated Protein C Resistance Increases the Risk Of Venous Thrombosis: a Prospective Study In 104 Patients with Unexplained Thrombosis
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Research
VOLUME: 45 ISSUE: 1
P: 14-18
March 2003

Activated Protein C Resistance Increases the Risk Of Venous Thrombosis: a Prospective Study In 104 Patients with Unexplained Thrombosis

Gulhane Med J 2003;45(1):14-18
Muhammed Wael ABUGHOUSH 1
Münzer Al RASHED 2
1. Senior Officer (Hematology), Laboratory Department, King Hussein Medical Center/ Jordan
2. GATA School of Medicine Department of Biochemistry and Clinical Biochemistry Etlik, Ankara, Turkey
No information available.
No information available
Accepted Date: 18.01.2003
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ABSTRACT

Resistance to activated protein C (APC) is fairly common inherited risk factor for venous thrombosis. The inherited abnormality is recently being considered to be a major hereditary disorder associated with elevated risk of venous thrombosis. In this study we determined the activated protein C resistance in 104 patients with deep vein thrombosis (DVT) with a mean age of 35 years. Protein C (PC) and Protein S (PS) activities as well as antithrombin III (ATIII) levels were also determined. Control group was comprised of 110 healthy, age and sex matched individuals. Activated protein C resistance positivity was determined as 33.6% and 4.5% (p<0.001) in deep vein thrombosis patients and control group, respectively. In parallel to light of the medical literature information, high prevalence of activated protein C resistance among young persons with history of venous thrombosis was re-emphasized.

Keywords:
Activated Protein C Resistance, Factor V Mutation, Deep Vein Thrombosis, Thrombophilia, Pulmonary Embolism (PE)