Case Report

Vitamin B12 deficiency associated with three-month use of proton-pump inhibitor in a child with chronic graft-versus-host disease

10.5455/gulhane.172354

  • Erman Ataş
  • Orhan Gürsel
  • İbrahim Eker
  • Ahmet Emin Kürekçi
  • Demet Altun
  • Utku Pamuk

Received Date: 06.11.2014 Accepted Date: 06.04.2015 Gulhane Med J 2016;58(2):197-199

Prolonged use of proton-pump inhibitors (PPI) may result in vitamin B12 deficiency as a consequence of impaired release of protein-bound dietary vitamin B12 from food in a nonacid environment. Herein, we described a case of vitaminB12 deficiency associated with three months use of PPI which was used to reduce gastric side effects of steroid in a patient with chronic graft versus host disease (cGVHD). Malabsorption of proteinbound vitamin B12 has been demonstrated with the prolonged use of PPI. Although monitoring these patients is not routinely recommended for side effects, patients with chronic disease should be followed-up more carefully.

Keywords: Proton-pump inhibitors, vitamin B12 deficiency