Original Article

Relation between PSA density and histologically proven chronic prostatitis


  • Ercan Malkoç
  • Ferhat Ateş
  • Sami Uğuz
  • Furkan Dursun
  • Ahmet Kenan Karademir
  • Cüneyt Adayener
  • Kadir Vehbi Baykal

Received Date: 13.02.2012 Accepted Date: 01.05.2012 Gulhane Med J 2013;55(1):18-21


Prostate-specific antigen (PSA) may elevate in case of prostate cancer, benign prostatic hyperplasia (BPH) as well as chronic prostatitis. In chronic prostatitis and BPH distinction PSA, free / total PSA ratio isn’t usefull. The aim of this study is to question the place of PSA density in the distinction of BPH and prostatitis.

Materials and Methods:

In our clinic BPH pre - diagnosed, data of transurethral resection of prostate (TUR-P) performed and histologically diagnosed as no chronic prostatitis observed (group 1), with TUR-P performed but chronic prostatitis diagnosed (group 2) patients were retrospectively analyzed. The age, PSA, biopsy history, prostate size and PSA density (PSAD = PSA level / prostate volume) of patients were recorded.


Chronic prostatitis was determined in 100 of 641 patients (%15. 6). Biopsy before TUR-P was performed to 28 patients in the chronic prostatitis group, and 27 patients in BPH group (n=100) and in only 4 patients (%14. 3) in the chronic prostatitis group pathological evidence of prostatitis was determined. PSA (p<0.001) and prostate volume (p=0.017) was larger in the chronic prostatitis group when compared with the BPH group. Also PSA density (p<0.001) was higher.


PSA density was higher in patients with chronic prostatitis.

Keywords: BPH, Chronic prostatitis, PSA density