Original Article

Preparation and in vitro evaluation of methylene blue films for treatment of oral mucosal diseases

10.26657/gulhane.00066

  • Özgür Esim

Received Date: 29.03.2019 Accepted Date: 11.04.2019 Gulhane Med J 2019;61(3):109-113

Aims:

The aim of this work was to develop and characterize the buccal films of methylene blue (MB) using natural polysaccharide pullulan and maltodextrin and to evaluate buccal films in vitro for the application in oral mucosal diseases.

Methods:

The mucoadhesive buccal films of methylene blue were prepared by solvent casting technique using maltodextrin and pullulan at different ratios. Mechanical properties and disintegration time of the films were evaluated and sample sizes were chosen as described in pharmacopeias.

Results:

After statistical evaluation using student’s t test, it is found that polymer type and concentrations affected both of the disintegration time and mechanical properties (p<0.05). The disintegration time of all the prepared formulations were less than 180 sec. and all formulations showed moderate mechanical strength (0.110 ± 0.034 to 0.783 ± 0.128 kgf ).

Conclusions:

From the experimental data of our study it can be concluded that optimized formulations of MB loaded buccal films can be an adjunct to the therapy to complete eradication of the diseases in future.

Keywords: Methylene Blue, Buccal Film, Pullulan, Maltodextrin, Propylene Glycol.