Aims:
We aimed to evaluate whether there is a specific subgroup of patients who benefit most from PSAD screening according to their prostate volume.
Methods:
Transrectal ultrasound guided prostate biopsy performed patients were stratified in five groups according to their prostate size. PSAD values were compared between groups, and the diagnostic accuracy of PSAD was evaluated for different prostate volumes.
Results:
Of 326 patients 98 (30.0%) had pCa. While total PSA and PSAD between pCa(+) and (-) patients were significantly higher in group 1,2 and 3, the differences was not significant in group 4 and 5. The highest AUC value was achieved for group 3 and the lowest for group 5. The optimal cutoff values were different between groups.
Conclusions:
Demonstrating the greatest diagnostic accuracy of PSAD in prostates ≥60 and <80 cc makes an invaluable contribution to the current literature and would be a reference point for further studies.
Keywords: Prostate-spesific antigen, PSA density, prostate size, prostate cancer, screening
