Resistance to activated protein C (APC) is fairly common inherited risk factor for venous thrombosis. The inherited abnormality is recently being considered to be a major hereditary disorder associated with elevated risk of venous thrombosis. In this study we determined the activated protein C resistance in 104 patients with deep vein thrombosis (DVT) with a mean age of 35 years. Protein C (PC) and Protein S (PS) activities as well as antithrombin III (ATIII) levels were also determined. Control group was comprised of 110 healthy, age and sex matched individuals. Activated protein C resistance positivity was determined as 33.6% and 4.5% (p<0.001) in deep vein thrombosis patients and control group, respectively. In parallel to light of the medical literature information, high prevalence of activated protein C resistance among young persons with history of venous thrombosis was re-emphasized.
Keywords: Activated Protein C Resistance, Factor V Mutation, Deep Vein Thrombosis, Thrombophilia, Pulmonary Embolism (PE)
