Data regarding the relationship between circulating hormone levels and polyp formation is lacking. In the present, we aimed to assess whether any relationship exists between the endometrial polyp formation and basal circulating estradiol levels in infertility population. Inclusion criteria were as follows; age ≥23 and <40, BMI ≥18 and <31 kg/m2, FSH <15 mIU/ml. Study group (n=114) was selected among patients who were detected to have polyps at the hysteroscopy, followed by a pathologic confirmation. Study group was further subdivided into two; those with polyps ≤10 mm (Group 1, n=71) and those with polyps >10 mm indiameter (Group 2, n=43). Following the stratification of the patients in the polyp group according to age and BMI, a control group was constituted from those who had no polyp and who was the appropriate for the age and BMI groups (n=114). Groups were compared in terms of demographic and clinical characteristics. No parameters compared significantly differed between polyp and control groups. Serum estradiol levels were higher in Group 2 than in Group 1, even if statistically non-significant (49.8±25.8 versus 59.8±29.0, respectively; p=0.058). In conclusion, basal serum estradiol levels do not differ between women with and without endometrial polyp, in infertility population and the increase in polyp dimensions has no association with serum estradiol levels.

Keywords: Endometrial polyp; infertility; hysteroscopy; serum estradiol.