Comparison of Transdermal and Oral Progestin Combinations in Transdermal Estrogen Replacement Therapy: Effects on Serum Lipids and Lipoproteins

  • Reşide ÖNALAN
  • Göğşen ÖNALAN
  • Belgin SELAM
  • Münire AKAR

Received Date: Accepted Date: 06.10.2004 Gulhane Med J 2004;49(4):311-314


We compared metabolic effects of transdermal and oral progestin combinations in postmenopausal women receiving transdermal estrogen replacement therapy.

Study Design:

One hundred fourteen postmenopausal women were randomized to receive either transdermal continous 17β estradiol, 0.05 mg/day with transdermal cyclic norethisterone acetate, 0.25 mg/day or transdermal continous 17β estradiol, 0.05 mg/day with oral cyclic medroxiprogesteron acetate, 10mg/day. Women in two groups were studied for one year. Lipoprotein profiles at 3,6 and 12 months were compared with baseline values by means of analysis of variance.


Plasma total cholesterol, low (LDL) and high (HDL) density lipoprotein and trigliserides were all significatly reduced.


Transdermal and oral progestin combinations in transdermal estrogen replacement therapy have similar effects on serum lipids and lipoproteins.

Keywords: Transdermal, Postmenopausal, Estradiol, Progestin, Plasma Lipids, Plasma lipoproteins, Cholesterol