GULHANE MEDICAL JOURNAL 2011 , Vol 53 , Issue 2
The effect of cytogenetic analysis results on prognosis in cases with myelodysplastic syndrome
Şefik Güran1, Cengiz Beyan2, Yusuf Tunca3, Salih Kozan3, Deniz Torun3, Ahmet Ifran2, Kürşat Kaptan2, Ali Uğur Ural2, Oral Nevruz2, Ferit Avcu2, Türker Çetin2, Davut Gül3,4, Muhterem Bahçe3
1 GATF Tıbbi Biyoloji Anabilim Dalı
2 GATF Hematoloji Bilim Dalı
3 GATF Tıbbi Genetik Bilim Dalı
4 GATA Yüksek Bilim Kurulu Üyesi
Cytogenetic analysis has a significant role in establishing diagnosis and prognostic evaluation of patients with myelodysplastic syndrome and is an important factor in selecting treatment type and evaluation of treatment response. The aim of this study was to evaluate retrospectively classical cytogenetic analysis results in patients with myelodysplastic syndrome followed between 2004 and 2009. Sixty eight patients with a mean age of 54.53±21.23 years (mean±standard deviation), range between 20-85 years and 49 of them as male were enrolled in the study. No metaphase was observed in 4 cases. Cytogenetic abnormalities were detected in 8 out of 64 (12.5%) patients diagnosed to have myelodysplastic syndrome and given cytogenetic analysis result. The most frequent abnormality observed in our study was loss of Y chromosome (-Y) with a rate of 6.25%. Fifty eight patients were in good risk group, 4 patients were in intermediate risk group and 2 patients were in poor risk group on the basis of cytogenetic results classified according to the risk categories of International Prognostic Scoring System. Two of the patients in poor and intermediate prognostic risk groups later transformed to acute myeloid leukemia. As a conclusion, cytogenetic investigations have a significant role in both prognostic evaluation and defining risk factors with regard to treatment in patients with myelodysplastic syndrome. However future routine use of molecular techniques together with classical chromosomal analyses will guide physicians in approaching this patient group. Keywords : Myelodysplastic syndromes, prognosis, cytogenetic analysis, diagnosis, medical therapy management