¹University of Health Sciences, Gülhane Faculty of Medicine, Department of Rheumatology, Ankara, Turkey DOI : 10.26657/gulhane.00042 Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is an elderlyonset rare disease. The clinical picture is particularly characterized by arthritis of the peripheral joints, tenosynovitis and edema in the hand and foot dorsum, especially in patients aged 65 years and over. Clinicians should be cautious in such cases as the most important mechanism responsible for pathogenesis may be secondary to an underlying malignancy. In our patient, RS3PE was diagnosed as a result of laboratory, radiological examinations in a patient who presented with symmetrical arthritis in peripheral joints and pitting edema in hand and foot dorsum. Keywords : Seronegative, symmetrical synovitis, pitting edema, inflammatory disease